Title of article
New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template
Author/Authors
Richard E. Mewshaw، نويسنده , , James A. Nelson، نويسنده , , Uresh S. Shah، نويسنده , , Xiaojie Shi، نويسنده , , Hossein Mazandarani، نويسنده , , Joseph Coupet، نويسنده , , Karen Marquis، نويسنده , , Julie A. Brennan، نويسنده , , Terrance H. Andree، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
2593
To page
2598
Abstract
The synthesis of several-bioisosteric analogs based on the 3-OH-phenoxyethylamine dopamine D2 agonist template (i.e., 3) is described. The benzimidazol-2-ones and benzthioimidazol-2-ones (7–10) and 2-trifluoromethyl-benzimidazole (13) were observed to have excellent affinity for the D2 receptor.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790384
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