Title of article
Syntheses of novel antitumor dihydroxanthone derivatives with inhibitory activity against DNA topoisomerase II
Author/Authors
Seiichi Sato، نويسنده , , Yasuyo Suga، نويسنده , , Toshihiko Yoshimura، نويسنده , , Ryusuke Nakagawa، نويسنده , , Takashi Tsuji، نويسنده , , Ken Umemura، نويسنده , , Toshiwo Andoh، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
2653
To page
2656
Abstract
A series of methoxycarbonyl group modified nidulalin A analogs were synthesized to improve stability against esterases. The amide derivatives showed cytotoxic activity along with inhibitory activity against DNA topoisomerase II. Among the analogs, amide 9a exhibited antitumor activity in Colon 26 murine tumor model.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790400
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