Title of article
Leishmanicidal activity of combretastatin analogues and heteroanalogues
Author/Authors
Benedicto Del Rey Herrero، نويسنده , , Angel C. Ramos، نويسنده , , Esther Caballero، نويسنده , , Alba Inchaustti، نويسنده , , Gloria Yaluff، نويسنده , , Manuel Medarde، نويسنده , , Antonieta Rojas de Arlas، نويسنده , , Arturo San Feliciano، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
2711
To page
2714
Abstract
We have investigated the in vitro leishmanicidal activity of representative members from series II–V of combretastatin analogues and heteroanalogues. Most of them exhibited different degrees of activity against various strains of Leishmania spp. The diaryl(heteroaryl)ethane system or the more complex fused heterocyclic stilbenoids, constitute useful skeletal bases to support some kind of antiparasitic activity. Particularly, the incorporation of 2-furyl substituents led to potent antileishmanial compounds, which have been selected for in vivo testing on murine models.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790411
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