Author/Authors :
Jeffrey H. Toney، نويسنده , , Kelly A. Cleary، نويسنده , , Gail G. Hammond، نويسنده , , Xiling Yuan، نويسنده , , Walter J. May، نويسنده , , Steven M. Hutchins، نويسنده , , Wallace T. Ashton، نويسنده , , Dana E. Vanderwall، نويسنده ,
Abstract :
Resistance to carbapenem antibiotics in Gram-negative bacteria is due, in part, to expression of a wide spectrum metallo-β-lactamase, which renders the drug inactive. Biphenyl tetrazoles containing 3-n-butyl-1-phenylpyrazole-5-carboxylates or the corresponding 5-ethyl esters were found to inhibit metallo-β-lactamases as well as renal dehydropeptidase I to a lesser extent.
