Title of article
Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin
Author/Authors
Andrzej W. Lipkowski، نويسنده , , Aleksandra Misicka، نويسنده , , Peg Davis، نويسنده , , Dagmar Stropova، نويسنده , , Jacqueline Janders، نويسنده , , Magdalena Lachwa، نويسنده , , Frank Porreca، نويسنده , , Henry I. Yamamura، نويسنده , , Victor J. Hruby، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
2763
To page
2766
Abstract
The synthesis and biological activity of two fragments of the very potent opioid peptide biphalin, showed that Tyr-D-Ala-Gly-Phe-NH-NH<-Phe is the minimal fragment necessary to express equal affinities and the same biological activity profile as the parent biphalin. The replacement of N′-Phe with other L- or D- lipophilic amino acids showed the possibility of modification of receptor efficacy of the analogues.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790421
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