Title of article
Synthesis and pharmacological profile of 1-aryl-3-substituted pyrrolo[3,2-c]quinolines
Author/Authors
Eul Kgun Yum، نويسنده , , Seung Kyu Kang، نويسنده , , Sung-Soo Kim، نويسنده , , Joong-Kwon Choi، نويسنده , , Hyae Gyeong Cheon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
2819
To page
2822
Abstract
A series of 1-aryl-3-substituted pyrrolo[3,2-c]quinolines were synthesized and evaluated for their anti-ulcer activity. While 3-substituents of pyrrolo[3,2-c]quinolines mostly affected the in vitro H+/K+ ATPase activity, 1-aryl substituents of pyrrolo[3,2-c]quinolines affected the in vivo gastric acid secretion. In addition, the compounds with good in vivo activity protected from ethanol-induced ulcer.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790432
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