Author/Authors :
Yingsheng Zhang، نويسنده , , Dongmei Li، نويسنده , , Jon C. Houtman، نويسنده , , Donald T. Witiak، نويسنده , , Jo Seltzer، نويسنده , , Paul J. Bertics، نويسنده , , Charles T. Lauhon، نويسنده ,
Abstract :
A novel series of hydroxamate/urea-based inhibitors of gelatinases has been discovered via solid-phase combinatorial chemistry. SAR of P1′, P2′, and P3′ has been exploited and structures different from traditional succinate-based MMP inhibitors have been found.
