Author/Authors :
Mohammad R. Marzabadi، نويسنده , , Xingfang Hong، نويسنده , , Dhanapalan Nagarathnam، نويسنده , , ShouWu Miao، نويسنده , , George Chiu، نويسنده , , Wai C. Wong، نويسنده , , John M. Wetzel، نويسنده , , James Fang، نويسنده , , Carlos Forray، نويسنده , , Tsing B. Chen، نويسنده , , Stacey S. OʹMalley، نويسنده , , Raymond S. L. Chang، نويسنده , , Charles Gluchowski، نويسنده ,
Abstract :
A series of analogs of SNAP 5150 containing heteroatoms at C2 or C6 positions is described. Herein, we report that the presence of alkyl substituted heteroatoms at the C2(6)-positions of the dihydropyridine are well tolerated. In addition, 15 inhibited the phenylephrine induced contraction of dog prostate tissue with a Kb of 1.5 nM and showed a Kb (DBP, dogs, μg/kg)/Kb (IUP, dogs, μg/kg) ratio of 14.8/2.5.
