Title of article
Interaction of tyrosyl aryl dipeptides with S. aureus tyrosyl tRNA synthetase: Inhibition and crystal structure of a complex
Author/Authors
Richard L. Jarvest، نويسنده , , John M. Berge، نويسنده , , Catherine S. V. Houge-Frydrych، نويسنده , , Cheryl Janson، نويسنده , , Lucy M. Mensah، نويسنده , , Peter J. OʹHanlon، نويسنده , , Andrew Pope، نويسنده , , S. Adrian Saldanha، نويسنده , , Xiayang Qiu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
2859
To page
2862
Abstract
Tyrosyl aryl dipeptide inhibitors of S. aureus tyrosyl tRNA synthetase have been identified with IC50 values down to 0.5 μM. A crystal structure of the enzyme complexed to one of the inhibitors shows occupancy of the tyrosyl binding pocket coupled with inhibitor interactions to key catalytic residues.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790440
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