2-Naphthylcarbapenems: Broad spectrum antibiotics with enhanced potency against MRSA
Author/Authors :
Mark L. Greenlee، نويسنده , , Frank DiNinno، نويسنده , , Jeffrey J. Herrmann، نويسنده , , Cynthia Jaworsky، نويسنده , , David A. Muthard، نويسنده , , Thomas N. Salzmann، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
Pages :
4
From page :
2893
To page :
2896
Abstract :
A regioisomeric set of 2-naphthylcarbapenems featuring cationic substituents was synthesized. Optimal placement of the cationic group was found to markedly improve activity against methicillin-resistant staphylococci while maintaining a good spectrum of gram-negative activity.
