Title of article
The synthesis and anti-MRSA activity of amidinium-substituted 2-dibenzofuranylcarbapenems
Author/Authors
Joanne B. Laub، نويسنده , , Mark L. Greenlee، نويسنده , , Frank DiNinno، نويسنده , , Joann L. Huber، نويسنده , , Jon G. Sundelof، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
2973
To page
2976
Abstract
A series of amidinium-substituted 2-dibenzofuranylcarbapenems with potent activity against MRSA has been synthesized via a Stille cross-coupling reaction. These new carbapenems show reduced serum protein binding and improved in vivo efficacy as a consequence of the positively charged amidinium substituent.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790463
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