Author/Authors :
Masahiko Hagihara، نويسنده , , Hiroto Kashiwase، نويسنده , , Tetsushi Katsube، نويسنده , , Tomio Kimura، نويسنده , , Tomoaki Komai، نويسنده , , Kenji Momota، نويسنده , , Toshinori Ohmine، نويسنده , , Takashi Nishigaki، نويسنده , , Satoshi Kimura، نويسنده , , Kaoru Shimada، نويسنده ,
Abstract :
Synthesis and anti-HIV activity of a series of novel arylpiperazinyl fluoroquinolones are reported. In the SAR study, the aryl substituents on the piperazine nitrogen were found to play an important role for the anti-HIV-1 activity. A few of the compounds exhibited potent ant-HIV activity: IC50= 0.06μM in chronically infected cells.
