Title of article
An efficient synthesis of a 4′-phosphonodifluoromethyl-3′-formyl-phenylalanine containing Src SH2 ligand
Author/Authors
William C. Shakespeare، نويسنده , , Regine S. Bohacek، نويسنده , , Surinder S. Narula، نويسنده , , Mihai D. Azimioara، نويسنده , , Ruth W. Yuan، نويسنده , , David C. Dalgarno، نويسنده , , Laura Madden، نويسنده , , Martyn C. Botfield، نويسنده , , Dennis A. Holt، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
3109
To page
3112
Abstract
A CuBr-mediated, regioselective cross-coupling between methyl 2,5-diiodobenzoate (4) and [(diethoxyphosphinyl)difluoromethyl]zinc bromide is reported. Palladium-catalyzed incorporation of an amino acid side chain, followed by subsequent modifications resulted in the rapid construction of 2. Compound 2 was designed to engage Cys188 of the Src SH2 domain, however, this was not observed spectroscopically.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790489
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