Author/Authors :
Stuart Bailey، نويسنده , , Brian Bolognese، نويسنده , , Andrew Faller، نويسنده , , Pearl Louis-Flamberg، نويسنده , , David T. MacPherson، نويسنده , , Ruth J. Mayer، نويسنده , , Lisa A. Marshall، نويسنده , , Peter H. Milner، نويسنده , , Jayshree Mistry، نويسنده , , David G. Smith، نويسنده , , John G. Ward، نويسنده ,
Abstract :
Using a variety of α-hydroxy hydroxamic acid derivatives, the size and shape of the S1′ pocket for the CD23 processing metalloprotease has been explored. It has been demonstrated that a P1′ 2-naphthylmethyl group occupies most of the available space and gives excellent selectivity against fibroblast collagenase (matrix metalloproteinase-1, MMP-1) and other MMPs.
