Author/Authors :
Sang-sup Jew، نويسنده , , Hee-Jin Kim، نويسنده , , Myoung Goo Kim، نويسنده , , Eun-Young Roh، نويسنده , , Chung Il Hong، نويسنده , , Joon-Kyum Kim، نويسنده , , Jun-Hee Lee، نويسنده , , Heesoon Lee، نويسنده , , Hyeung-geun Park، نويسنده ,
Abstract :
A series of C(7)-N-alkylaminoethyl-C(10), C(11)-methylenedioxy- and ethylenedioxy-camptothecin (3a–g, 4a–h) were prepared. Their syntheses and in vitro cytotoxicity were reported. Among 15 derivatives, 3a and 3b showed more potent cytotoxicity than Camptothecin, especially in CAOV-3 cell line.
