Title of article
Synthesis and evaluation of benzoxazinones as HIV-1 reverse transcriptase inhibitors. Analogs of Efavirenz (SUSTIVA )
Author/Authors
Mona Patel، نويسنده , , Robert J. McHugh Jr.، نويسنده , , Beverly C. Cordova، نويسنده , , Ronald M. Klabe، نويسنده , , Susan Erickson-Viitanen، نويسنده , , George L. Trainor، نويسنده , , Soo S. Ko، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
3221
To page
3224
Abstract
Two series of benzoxazinones differing in the aromatic substitution pattern were prepared and evaluated as HIV-1 reverse transcriptase inhibitors. The 5-fluoro (5a-d) and 6-nitro (5e-h) substituted compounds displayed activity comparable or better than Efavirenz, the lead structure of the series.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790511
Link To Document