Author/Authors :
Mark L. Greenlee، نويسنده , , Joanne B. Laub، نويسنده , , Gregory P. Rouen، نويسنده , , Frank DiNinno، نويسنده , , Milton L. Hammond، نويسنده , , Joann L. Huber، نويسنده , , Jon G. Sundelof، نويسنده , , Gail G. Hammond، نويسنده ,
Abstract :
The synthesis and biological evaluation of a series of dicationic-substituted 2-fluorenonylcarbapenems is described. This class of compounds showed enhanced water solubility while maintaining potent activity against MRS. Introduction of a 1-β-methyl substituent was found to improve pharmacokinetics.
