Title of article
Dicationic 2-fluorenonylcarbapenems: Potent anti-MRS agents with improved solubility and pharmacokinetic properties
Author/Authors
Mark L. Greenlee، نويسنده , , Joanne B. Laub، نويسنده , , Gregory P. Rouen، نويسنده , , Frank DiNinno، نويسنده , , Milton L. Hammond، نويسنده , , Joann L. Huber، نويسنده , , Jon G. Sundelof، نويسنده , , Gail G. Hammond، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
3225
To page
3230
Abstract
The synthesis and biological evaluation of a series of dicationic-substituted 2-fluorenonylcarbapenems is described. This class of compounds showed enhanced water solubility while maintaining potent activity against MRS. Introduction of a 1-β-methyl substituent was found to improve pharmacokinetics.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790512
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