Author/Authors :
Shinichiro Ono، نويسنده , , Shigeki Kuwahara، نويسنده , , Masahiro Takeuchi، نويسنده , , Hiroshi Sakashita، نويسنده , , Youichiro Naito، نويسنده , , Takao Kondo، نويسنده ,
Abstract :
We report the syntheses and evaluation of amidinobenzofuran derivatives as tryptase inhibitors. Among the compounds we evaluated, 1,5-Bis[4-(5-amidinobenzofuran-2-ylcarbonyl)piperazinylcarbonylmethoxy]cyclooctane 26 (AY0068) was found to be a selective and potent non-peptide inhibitor. 26 was effective in PCA reaction in rats without showing antihistaminic activity.
