Title of article :
4-Pyridin-5-yl-2-(3,4,5-trimethoxyphenylamino)pyrimidines: Potent and selective inhibitors of ZAP 70
Author/Authors :
David Moffat، نويسنده , , Peter Davis، نويسنده , , Martin Hutchings، نويسنده , , Jeremy Davis، نويسنده , , Daniel Berg، نويسنده , , Mark Batchelor، نويسنده , , James Johnson، نويسنده , , James OʹConnell، نويسنده , , Richard Martin، نويسنده , , Tom Carabbe، نويسنده , , Jean Delgado، نويسنده , , Martin Perry، نويسنده ,
Abstract :
Activation of the tyrosine kinase ZAP 70 has been shown to be crucial to the transduction of the T-cell receptor signalling pathway, which leads ultimately to proliferation, cytokine gene expression and T-cell effector functions. A series of 2-phenylaminopyrimidines have been identified as potent and selective inhibitors of ZAP 701.
