Title of article :
Novel synthetic oleanane triterpenoids: A series of highly active inhibitors of nitric oxide production in mouse macrophages
Author/Authors :
Ta-i Honda، نويسنده , , BarbieAnn V. Rounds، نويسنده , , Lothar Bore، نويسنده , , Frank G. Favaloro Jr.، نويسنده , , Gordon W. Gribble، نويسنده , , Nanjoo Suh، نويسنده , , Yongping Wang، نويسنده , , Michael B. Sporn، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
Abstract :
Novel oleanane triterpenoids with modified rings A and C were designed and synthesized. Among them, methyl 2-carboxy-3,12-dioxooleana-1,9-dien-28-oate showed similar high inhibitory activity (IC50 = 0.8 nM) to 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), which we have synthesized previously, against production of nitric oxide induced by interferon-γ in mouse macrophages.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
