Author/Authors :
Tianbao Lu، نويسنده , , Richard M. Soll، نويسنده , , Carl R. Illig، نويسنده , , Roger Bone، نويسنده , , Larry Murphy، نويسنده , , John Spurlino، نويسنده , , F. Raymond Salemme، نويسنده , , Bruce E. Tomczuk، نويسنده ,
Abstract :
The structure–activity relationships of a novel series of non-amide-based thrombin inhibitors are described. Exploration of the P2 and the aryl binding region for this series has identified optimal groups for achieving nanomolar potency. The binding modes of these optimal groups have been confirmed by X-ray structural analysis.
