Title of article :
Structure–activity relationships of trans-3,5-disubstituted pyrrolidinylthio-1β-methylcarbapenems. Part 2: J-111,225, J-114,870, J-114,871 and related compounds
Author/Authors :
Hideaki Imamura، نويسنده , , Norikazu Ohtake، نويسنده , , Aya Shimizu، نويسنده , , Hiroki Sato، نويسنده , , Yuichi Sugimoto، نويسنده , , Shunji Sakuraba، نويسنده , , Hideo Kiyonaga، نويسنده , , Chihiro Suzuki-Sato، نويسنده , , Masato Nakano، نويسنده , , Rie Nagano، نويسنده , , Koji Yamada، نويسنده , , Terutaka Hashizume، نويسنده , , Hajime Morishima، نويسنده ,
Abstract :
Through further derivatization of J-111,347 (Figure 1 and Scheme 1), a trans-3,5-disubstituted pyrrolidinylthio-1β-methylcarbapenem, undesired epileptogenicity in a rat intracerebroventricular assay (200 μg/rat) could be eliminated to afford J-111,225 (Figure 1 and Scheme 1), J-114,870 ( Figure 1 and Scheme 1) and J-114,871 ( Figure 1 and Scheme 1) which preserved comparable broad antimicrobial activity.
