Author/Authors :
Bharat Lagu، نويسنده , , Dake Tian، نويسنده , , George Chiu، نويسنده , , Dhanapalan Nagarathnam، نويسنده , , James Fang، نويسنده , , Quanrong Shen، نويسنده , , Carlos Forray، نويسنده , , Richard W. Ransom، نويسنده , , Raymond S. L. Chang، نويسنده , , Kamlesh P. Vyas، نويسنده , , Kanyin Zhang، نويسنده , , Charles Gluchowski، نويسنده ,
Abstract :
Furo[3,4-d]pyrimidinones were found to be metabolites of dihydropyrimidinones such as 1a–b that are subtype-selective antagonists of the α1a-adrenergic receptor. A versatile synthesis that provides access to furo[3,4-d]pyrimidinones in high yield and in enantiomerically pure forms is described along with structure–activity relationships in the series.
