Title of article
Synthesis and evaluation of furo[3,4-d]pyrimidinones as selective α1a-adrenergic receptor antagonists
Author/Authors
Bharat Lagu، نويسنده , , Dake Tian، نويسنده , , George Chiu، نويسنده , , Dhanapalan Nagarathnam، نويسنده , , James Fang، نويسنده , , Quanrong Shen، نويسنده , , Carlos Forray، نويسنده , , Richard W. Ransom، نويسنده , , Raymond S. L. Chang، نويسنده , , Kamlesh P. Vyas، نويسنده , , Kanyin Zhang، نويسنده , , Charles Gluchowski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
175
To page
178
Abstract
Furo[3,4-d]pyrimidinones were found to be metabolites of dihydropyrimidinones such as 1a–b that are subtype-selective antagonists of the α1a-adrenergic receptor. A versatile synthesis that provides access to furo[3,4-d]pyrimidinones in high yield and in enantiomerically pure forms is described along with structure–activity relationships in the series.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790597
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