Author/Authors :
Pier Giovanni Baraldi، نويسنده , , Barbara Cacciari، نويسنده , , Romeo Romagnoli، نويسنده , , Katia Varani، نويسنده , , Stefania Merighi، نويسنده , , Stefania Gessi، نويسنده , , Pier Andrea Borea، نويسنده , , Edward Leung، نويسنده , , Sarah L. Hickey، نويسنده , , Giampiero Spalluto، نويسنده ,
Abstract :
The synthesis and the preliminary biological evaluation of the first high affinity radioligand antagonist for the human A3 adenosine receptor, named [3H]-MRE 3008-F20 are reported. [3H]-MRE 3008-20 bound human A3 receptors expressed in CHO cells with KD and Bmax value of 0.82±0.08 nM and 297±28 fmol/mg of protein, respectively. [3H]-MRE 3008-F20 represents a useful tool for a further characterization of A3 adenosine receptor subtype.
