Title of article
Structure–activity relationships of carboxymethylpullulan-peptide-doxorubicin conjugates—systematic modification of peptide spacers
Author/Authors
Hideo Nogusa، نويسنده , , Toshiro Yano، نويسنده , , Nobukazu Kashima، نويسنده , , Keiji Yamamoto، نويسنده , , Satoshi Okuno، نويسنده , , Hiroshi Hamana، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
227
To page
230
Abstract
A series of carboxymethylpullulan (CMPul)-doxorubicin (DXR) conjugates bound by peptide spacers of different compositions and lengths were prepared and evaluated for their in vivo antitumor effects. Systematic study of the peptide spacers indicated that CMPul-DXR conjugates bound via appropriate dipeptide spacers were more potent than DXR.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790609
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