Design and synthesis of mimics of S-adenosyl- -homocysteine as potential inhibitors of erythromycin methyltransferases

A series of indanotriazine C-ribosides were prepared as SAH mimics, and tested for their ability to inhibit erythromycin resistance methylases Erm AM and Erm C′. A carbocyclic analogue derived from quinic acid was also synthesized and tested.