Author/Authors :
Chung-Kyu Ryu، نويسنده , , Hye-Young Kang، نويسنده , , Sang Kook Lee، نويسنده , , Kyung Ae Nam، نويسنده , , Chang Yong Hong، نويسنده , , Won-Gil Ko، نويسنده , , Byung-Hoon Lee، نويسنده ,
Abstract :
5-Arylamino-2-methyl-4,7-dioxobenzothiazoles were synthesized as inhibitors of cyclin-dependent kinase 4 (CDK4) and cytotoxic agents. Most of the 4,7-dioxobenzothiazoles exhibited selective inhibitory activities for the CDK4 and cytotoxic potential against human cancer cell lines.
