Author/Authors :
Masakazu Fujio، نويسنده , , Yoshifumi Togo، نويسنده , , Hideo Tomozane، نويسنده , , Takanobu Kuroita، نويسنده , , Yasunori Morio، نويسنده , , Jiro Katayama، نويسنده , , Yasuhiro Matsumoto، نويسنده ,
Abstract :
A series of benzamides was synthesized as selective agonists for the 5-HT1A receptor. It was found that (S)-N-{[1-(2-phenylethyl)pyrrolidin-2-yl]methyl}cyclohexanecarboxamide(7-(S)) has potent and selective agonistic activity for the 5-HT1A receptor (5-HT1A; Ki=0.49 nmol/L, D2; IC50=>1000 nmol/L, 5-HT2; Ki=240 nmol/L).
