Author/Authors :
Dirk A. Heerding، نويسنده , , Melanie Abruzzese، نويسنده , , Doreen Alberts، نويسنده , , Joelle Burgess، نويسنده , , James F. Callahan، نويسنده , , William F. Huffman، نويسنده , , Andrew G. King، نويسنده , , Stephen LoCastro، نويسنده , , Peter DeMarsh، نويسنده , , Louis M. Pelus، نويسنده , , Joanne S. Takata، نويسنده , , Pradip K. Bhatnagar، نويسنده ,
Abstract :
The activity of a novel series of peptidomimetic hematoregulatory compounds, designed based on a pharmacophore model inferred from the structure–activity relationships of a peptide SK&F 107647 (1), is reported. These compounds induce a hematopoietic synergistic factor (HSF) which in turn modulates host defense. The compounds may represent novel therapeutic agents in the area of hematoregulation.
Figure 1. Structure of SK&F 107647 (1).
