Author/Authors :
Conrad Kunick، نويسنده , , Christiane Schultz، نويسنده , , Thomas Lemcke، نويسنده , , Daniel W. Zaharevitz، نويسنده , , Rick Gussio، نويسنده , , Ravi K. Jalluri، نويسنده , , Edward A. Sausville، نويسنده , , Maryse Leost، نويسنده , , Laurent Meijer، نويسنده ,
Abstract :
9-Trifluoromethyl-paullones with a carbon chain in the 2-position were synthesized by palladium-catalyzed coupling reactions of a 2-iodoprecursor with terminal alkenes or alkynes, respectively. The introduction of a 2-cyanoethyl substituent led to a significant enhancement of CDK1/cyclin B inhibiting property and in vitro antiproliferative activity.
