• Title of article

    Membrane-permeant, bioactivatable analogues of cGMP as inducers of cell death in IPC-81 leukemia cells

  • Author/Authors

    Frank Schwede، نويسنده , , Odd T. Brustugun، نويسنده , , Michaela Zorn-Kruppa، نويسنده , , Stein O. D?skeland، نويسنده , , Bernd Jastorff، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2000
  • Pages
    3
  • From page
    571
  • To page
    573
  • Abstract
    We report an improved single-step synthesis to generate the membrane-permeant acetoxymethyl esters (AM-esters) of cGMP and three cGMP-analogues. These bioactivatable compounds were found to induce cell death in rat IPC-81 cells, a model system for acute myelocytic leukemia, in micromolar doses, while the corresponding non-modified cGMP-analogues were inactive.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2000
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    790689

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=790689