Pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation

A series of pyrrolo[3,2-c]pyridines, isosteres of the antithrombotic drug ticlopidine, has been synthesized and evaluated in vitro for the ability to inhibit aggregation of human platelet-rich plasma induced by adenosin 5′-diphosphate (ADP). Structure–activity relationships showed their antiplatelet effects to be related to the lipophilicity.