Title of article
Design and synthesis of anticonvulsive agents as γ-vinyl GABA-based potential dual acting prodrugs and their biological activities
Author/Authors
Yongchul Kim، نويسنده , , Long-Xuan Zhao، نويسنده , , Tae-Hyung Kim، نويسنده , , Sun-mi Je، نويسنده , , Eunkyung Kim، نويسنده , , Heesung Choi، نويسنده , , Whi-Gun Chae، نويسنده , , Minsoo Park، نويسنده , , Jongwon Choi، نويسنده , , Yurngdong Jahng، نويسنده , , Eung Seok Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
5
From page
609
To page
613
Abstract
For the development of new anticonvulsive agents, γ-vinyl GABA (vigabatrin) and GABA mimetics derivatives were covalently coupled as potential dual acting prodrugs and evaluated for their anticonvulsive activities. Among the prepared compounds, 11 showed the most potent anticonvulsive activity, a shorter onset time and a broader spectrum compared to vigabatrin.
Scheme 1.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790697
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