Title of article :
Inhibition of the ras-dependent mitogenic pathway by phosphopeptide prodrugs with antiproliferative properties
Author/Authors :
Wang-Qing Liu، نويسنده , , Michel Vidal، نويسنده , , Christophe Mathé، نويسنده , , Christian Perigaud، نويسنده , , Christiane Garbay، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Abstract :
Phosphopeptide prodrugs bearing two S-acyl-2-thioethyl (SATE) biolabile phosphate protections were developed. They are capable to inhibit the Shc/Grb2 interaction and MAP kinases (ERK1 and ERK2) phosphorylation in cellular assay. The S-acetyl-2-thioethyl (MeSATE) analogue showed an IC50 of 1 μM in the inhibition of the colony formation of tumor cell line NIH3T3/HER2.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
