Title of article :
Antitumor agents. Part 202: Novel 2′-amino chalcones: design, synthesis and biological evaluation
Author/Authors :
Yi Xia، نويسنده , , Zhengyu Yang، نويسنده , , Peng-Xia Liu، نويسنده , , Kenneth F. Bastow، نويسنده , , Yuka Nakanishi، نويسنده , , Kuo-Hsiung Lee، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Abstract :
New 4′,5′,2,3,4-substituted 2′-amino chalcones were synthesized and evaluated for cytotoxicity against a panel of human tumor cell lines. Several compounds displayed significant cytotoxicity. The most promising lead molecule (10) also had high activity toward multi-drug resistant KB-VIN, and ovarian 1A9 cell lines. 2′-Amino chalcones demonstrated significantly increased antitumor activity compared with the corresponding chalcones, while, the epoxide derivatives generally showed greatly reduced activity.
Scheme 1. General synthetic routes to 2′-amino chalcones.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters