Title of article :
N-Acyl phenylalanine analogues as potent small molecule VLA-4 antagonists
Author/Authors :
Li Chen، نويسنده , , Jefferson W. Tilley، نويسنده , , Tai-Nan Huang، نويسنده , , Dorota Miklowski، نويسنده , , Richard Trilles، نويسنده , , Robert W. Guthrie، نويسنده , , Kin Luk، نويسنده , , Angela Hanglow، نويسنده , , Karen Rowan، نويسنده , , Virginia Schwinge، نويسنده , , Barry Wolitzky، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Pages :
3
From page :
725
To page :
727
Abstract :
We have identified a series of low molecular weight (Mr<500) N-acylphenylalanines that are effective inhibitors of the VCAM-VLA-4 interaction. Investigation of the SAR of the N-acyl moiety led to the identification of N-benzylpyroglutamyl derivatives as being particularly potent.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2000
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
790724
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=790724
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