Title of article :
N-Benzylpyroglutamyl- -phenylalanine derivatives as VCAM/VLA-4 antagonists
Author/Authors :
Li Chen، نويسنده , , Jefferson W. Tilley، نويسنده , , Robert W. Guthrie، نويسنده , , Francis Mennona، نويسنده , , Tai-Nan Huang، نويسنده , , Gerry Kaplan، نويسنده , , Richard Trilles، نويسنده , , Dorota Miklowski، نويسنده , , Nicolas Huby، نويسنده , , Virginia Schwinge، نويسنده , , Barry Wolitzky، نويسنده , , Karen Rowan، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Pages :
5
From page :
729
To page :
733
Abstract :
A series of N-(N-benzylpyroglutamyl)-4-substituted- -phenylalanine derivatives was prepared as VLA-4/VCAM antagonists. Analogues substituted by electron deficient benzoylamino groups bearing bulky ortho substituents had low-nM potency in an ELISA assay and low-μM activity in a cell based assay.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2000
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
790725
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=790725
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