Author/Authors :
Dominique Potin، نويسنده , , Véronique Parnet، نويسنده , , Jean-Marie Teulon، نويسنده , , Françoise Camborde، نويسنده , , François Caussade، نويسنده , , Joëlle Meignen، نويسنده , , Daniel Provost، نويسنده , , Alix Cloarec، نويسنده ,
Abstract :
A series of 3-(4-piperidinylthio)-1H-indoles was synthesized and evaluated in mice in the phenylbenzoquinone(PBQ)-induced writhing and hot plate tests. Most of these compounds are good analgesics with activities comparable to that of morphine. Among them compound 1i (UP 237-61), which has a strong serotonin binding profile, has an interesting antinociceptive activity which is not reversed by naloxone.
