Author/Authors :
Richard F. Clark، نويسنده , , Zhenkun Ma، نويسنده , , Sanyi Wang، نويسنده , , George Griesgraber، نويسنده , , Michael Tufano، نويسنده , , Hong Yong، نويسنده , , Leping Li، نويسنده , , Xiaolin Zhang، نويسنده , , Angela M. Nilius، نويسنده , , Daniel T. W. Chu، نويسنده , , Yat Sun Or، نويسنده ,
Abstract :
A series of novel 6-O-substituted erythromycin A derivatives has been synthesized. Good in vitro antibacterial activity has been demonstrated for analogues incorporating a variety of structural features. The methodology disclosed is expected to find application in the design of future macrolide antibiotics that target the prevalent bacterial resistance problem.
