Author/Authors :
Damian O. Arnaiz، نويسنده , , Zuchun (Spring) Zhao، نويسنده , , Amy Liang، نويسنده , , Lan Trinh، نويسنده , , Marc Whitlow، نويسنده , , Sunil K. Koovakkat، نويسنده , , Kenneth J. Shaw، نويسنده ,
Abstract :
A series of indole and carbazole based inhibitors of factor Xa (FXa) has been investigated. The most potent compound inhibits FXa with a Ki of 0.2 nM and has 900- and 750-fold selectivity over thrombin and trypsin, respectively.
