Title of article
Discovery and evaluation of potent, tyrosine-based α4β1 integrin antagonists
Author/Authors
Sarah C. Archibald، نويسنده , , John C. Head، نويسنده , , Neil Gozzard، نويسنده , , David W. Howat، نويسنده , , Ted A. H. Parton، نويسنده , , John R. Porter، نويسنده , , Martyn K. Robinson، نويسنده , , Anthony Shock، نويسنده , , Graham J. Warrellow، نويسنده , , William M. Abraham، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
997
To page
999
Abstract
Using disulphide cysteine-based inhibitors as lead structures, this communication describes our strategy for identifying more stable, potent antagonists of the α4β1 integrin. These studies ultimately discovered potent, low molecular weight inhibitors based on -thioproline- -tyrosine.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790782
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