Title of article
Synthesis and evaluation of antiproliferative activity of a geldanamycin–Herceptin™ immunoconjugate
Author/Authors
Raya Mandler، نويسنده , , Ekaterina Dadachova، نويسنده , , James K. Brechbiel، نويسنده , , Thomas A. Waldmann، نويسنده , , Martin W. Brechbiel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
1025
To page
1028
Abstract
Geldanamycin was modified with 1,4-diaminobutane to introduce a primary amine that was subsequently employed to provide a maleimide for protein linkage. Monoclonal antibody Herceptin™ was then derivatized to generate thiol groups that reacted with the maleimide derivative to produce the immunoconjugate. The product showed antiproliferative activity greater than native Herceptin™.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790790
Link To Document