Title of article
Solid-phase parallel synthesis of azarene pyrrolidinones as factor Xa inhibitors
Author/Authors
Yong Gong، نويسنده , , Michael Becker، نويسنده , , Yong Mi Choi-Sledeski، نويسنده , , Roderick S. Davis، نويسنده , , Joseph M. Salvino، نويسنده , , Valeria Chu، نويسنده , , Karen D. Brown، نويسنده , , Henry W. Pauls، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
1033
To page
1036
Abstract
A focused library (4×14) prepared from 4-aminopyridine and 4-, 5-, and 6-azoindole templates was synthesized using 14 polymer supported 4-amido-2,3,5,6-tetrafluorophenyl (TFP) sulfonate esters inputs. Several compounds were identified as factor Xa inhibitors (IC50≤0.1 μM) helping to establish the SAR among these four series of azarene pyrrolidinones.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790792
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