Title of article
Examination of N-hydroxylation as a prerequisite mechanism of nitric oxide synthase inactivation
Author/Authors
Tristan S. Maurer، نويسنده , , IEEE Jianping Pan، نويسنده , , Brian P. Booth، نويسنده , , Thomas I. Kalman، نويسنده , , Ho-Leung Fung، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
1077
To page
1080
Abstract
-N5-(1-Hydroxyiminoethyl)-ornithine ( -NHIO) and -N6-(1-hydroxyiminoethyl)-lysine ( -NHIL) were synthesized and tested as potential intermediates in the mechanism-based inactivation of nitric oxide synthase (NOS) by -N5-iminoethyl-ornithine ( -NIO) and -N6-iminoethyllysine ( -NIL). Although these compounds were determined to be competitive inhibitors, mechanism-based inactivation was not observed.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790803
Link To Document