Title of article
Novel arylpiperazines as selective α1-adrenergic receptor antagonists
Author/Authors
Xiaobing Li، نويسنده , , William V. Murray، نويسنده , , Linda Jolliffe، نويسنده , , Virginia Pulito، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
1093
To page
1096
Abstract
A novel series of arylpiperazines has been synthesized and identified as antagonists of α1a adrenergic receptor (α1a-AR) implicated in benign prostatic hyperplasia. These compounds selectively bind to membrane bound α1a-AR with Kis as low as 0.66 nM. As such, these potentially represent a viable treatment for BPH without the side effects associated with known α1-adrenergic antagonists.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790807
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