Title of article
Cyclopentadienyltricarbonylrheniumbenzazepines: synthesis and binding affinity
Author/Authors
Gilles Tamagnan، نويسنده , , Ronald M. Baldwin، نويسنده , , Nora S. Kula، نويسنده , , Ross J. Baldessarini، نويسنده , , Robert B. Innis، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
1113
To page
1115
Abstract
Analogues of the benzazepine dopamine D1 receptor antagonist SCH-23390 incorporating the cyclo-pentadienyltricarbonyl-rhenium (CPTR) moiety were synthesized and evaluated pharmacologically. The CPTR derivatives retained affinity (0.3–2.9 nM) and D1 selectivity of the parent compound, supporting their use as neuropharmacological surrogates for 99mTc-labeled SPECT radiopharmaceuticals.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790812
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