Author/Authors :
Wuyi Wang، نويسنده , , Patrice Préville، نويسنده , , Nicolas Morin، نويسنده , , Samir Mounir، نويسنده , , Weizhong Cai، نويسنده , , M. Arshad Siddiqui، نويسنده ,
Abstract :
An in vitro assay based on the expression of Fluci reporter gene under the translational control of HCV IRES was used to evaluate and screen compound libraries. A structure–activity relationship study on a phenazine hit was conducted. Our data suggest that an intact phenazine or phenazine-like core with two distal polar substitutions is crucial for potency.
