Title of article
Synthesis and activity studies of conformationally restricted α-ketoamide factor Xa inhibitors
Author/Authors
Joseph Cacciola، نويسنده , , John M. Fevig، نويسنده , , Pieter F. W. Stouten، نويسنده , , Richard S. Alexander، نويسنده , , Robert M. Knabb، نويسنده , , Ruth R. Wexler، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
1253
To page
1256
Abstract
Conformationally restricted borolysine compounds containing a 2-(2-cyanophenylthio) benzoyl in the P3 position unexpectedly led to enhanced factor Xa inhibition. In an effort to improve both the potency and selectivity of this series by extending into the S′ domain, we have replaced the boronic acid with α-ketoamides, utilizing a novel process that was developed in our labs.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790845
Link To Document