Author/Authors :
Scott D. Kuduk، نويسنده , , Christina R. Harris، نويسنده , , Fuzhong F. Zheng، نويسنده , , Laura Sepp-Lorenzino، نويسنده , , Quathek Ouerfelli، نويسنده , , Neal Rosen، نويسنده , , Samuel J. Danishefsky، نويسنده ,
Abstract :
Geldanamycin (GDM) binds to the Hsp90 chaperone protein resulting in the degradation of several important signaling proteins. A series of GDM–testosterone linked hybrids has been synthesized and evaluated for activity against prostate cancer cell lines. The hybrid with the greatest activity exhibits potent and selective cytotoxicity against prostate cancer cells containing the androgen receptor.
