Title of article
Synthesis and binding to plant lectins of sulfur-containing analogues of βGal1,3αGalNAc (T-antigen)
Author/Authors
Hansj?rg Streicher، نويسنده , , Walther Schmid، نويسنده , , Irmgard Wenzl، نويسنده , , Christian Fiedler، نويسنده , , Hanspeter K?hlig، نويسنده , , Frank M. Unger، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
1369
To page
1371
Abstract
Analogues of the tumor-associated T-antigen (βGal1,3αGalNAc) containing 4,6-epidithio and 4,6-thietan modifications were synthesized from the α-allyl glycoside of βGalα1,3G1cNAc via suitable thiocyanate derivatives. Binding to three leguminous lectins as model systems was investigated in an enzyme-linked lectin assay (ELLA) and IC50 values comparable to the corresponding natural disaccharides T-antigen, lactose and N-acetyllactosamine were found.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790873
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